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Product Image-89157-028

8-Br-cGMP ≥96% (by HPLC)

Supplier: Enzo Life Sciences
Description: A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.

Product Image-89152-832

2',7'-Dichlorofluorescin diacetate ≥95% (by HPLC)

Catalog Number: (89152-832)
Supplier: Enzo Life Sciences
Description: Peroxynitrite indicator.
Image Unavailable-75835-458

Residual Solvents Class 2 - Mix C (8 Components), Restek

Catalog Number: (75835-458)
Supplier: Restek
Description: These mixtures reflect the changes made in USP30/NF25 effective July 1, 2008.

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Product Image-89164-678

Fingolimod hydrochloride ≥98% (by HPLC)

Supplier: Enzo Life Sciences
Description: Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A2 independently of sphingosine 1-phosphate receptors.

Product Image-89147-804

Olomoucine II ≥98% (by HPLC)

Catalog Number: (89147-804)
Supplier: Enzo Life Sciences
Description: Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.
Product Image-89158-310

Arachidonic acid ≥99% (by TLC)

Supplier: Enzo Life Sciences
Description: Precursor to a large family of eicosanoids. Acts as a second messenger independent of metabolism. Retrograde messenger in long-term potentiation in the nervous system. Inhibits ras-GAP. Activator for several protein kinase C (PKC) isotypes.

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Product Image-89156-844

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride ≥98% (by TLC)

Catalog Number: (89156-844)
Supplier: Enzo Life Sciences
Description: Binds to calmodulin, inhibiting Ca2+-calmodulin-regulated enzyme activity. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=25 µM). Cell permeable.
Image Unavailable-89158-356

Anandamide ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

Image Unavailable-89150-232

UCN-01 (from Streptomyces sp. MST-AS5345) ≥99% (by HPLC)

Catalog Number: (89150-232)
Supplier: Enzo Life Sciences
Description: Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.
Image Unavailable-89157-906

N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide ≥98% (by HPLC)

Supplier: Enzo Life Sciences
Description: Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.

Product Image-89157-838

K-252b ≥98% (by HPLC)

Catalog Number: (89157-838)
Supplier: Enzo Life Sciences
Description: General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).
Product Image-89151-590

8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt ≥98% (by HPLC)

Supplier: Enzo Life Sciences
Description: Specific, potent and membrane permeant activator of the Epac cAMP receptor.

Product Image-89157-828

5,6-Dichlorobenzimidazole-1-β-D-Ribofuranoside ≥97% (by TLC)

Catalog Number: (89157-828)
Supplier: Enzo Life Sciences
Description: DRB is a potent and specific inhibitor of casein kinase II (CKII, IC50~6 µM). It has been used to inhibit RNA polymerase II mediated-transcription which may be dependent on CKII and its interaction with ATF-1.
Image Unavailable-89151-500

8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer sodium salt ≥99% (by HPLC)

Supplier: Enzo Life Sciences
Description: Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP.

Image Unavailable-89149-530

Galiellalactone (from unidentified fungus MST-FP1888) ≥95% (by HPLC)

Catalog Number: (89149-530)
Supplier: Enzo Life Sciences
Description: Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.
Image Unavailable-89161-782

RK-682 ≥98% (by HPLC)

Supplier: Enzo Life Sciences
Description: RK-682 is a novel tyrosine phosphatase inhibitor isolated from Streptomyces sp. It inhibits the dual specificity VHR phosphatase (IC50=2.0µM) selectively over CD45 (IC50=54µM), Cdc25B and PTP1B (IC50~42µM). RK-682 inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea pig hippocampal CA1 neurons. Shows potent activity against HIV-1 protease.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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