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Image Unavailable-CH08072-5G

Fmoc-Gly-Gly-Gly-OH

Catalog Number: (CH08072-5G)
Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: Fmoc-Gly-Gly-Gly-OH, also known as Fmoc-tri-glycine, is a versatile peptide derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure allows for the efficient assembly of longer peptide chains, making it an invaluable tool for researchers in the fields of biochemistry and molecular biology. The practical applications of Fmoc-Gly-Gly-Gly-OH extend to the development of peptide-based therapeutics, where it serves as a building block for creating bioactive peptides with potential therapeutic properties. Additionally, its use in the synthesis of peptide libraries enables researchers to explore a wide range of biological activities, facilitating drug discovery and development. With its high purity and stability, Fmoc-Gly-Gly-Gly-OH stands out as a reliable choice for professionals seeking to enhance their peptide synthesis workflows.

New Product


Product Image-10108-294

Anti-SLC22A1 Rabbit Polyclonal Antibody

Catalog Number: (10108-294)
Supplier: Prosci
Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
Product Image-10104-578

Anti-BPNT1 Rabbit Polyclonal Antibody

Catalog Number: (10104-578)
Supplier: Prosci
Description: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
Product Image-89154-424

Anti-GST-PI Mouse Monoclonal Antibody

Catalog Number: (89154-424)
Supplier: Enzo Life Sciences
Description: The GST Family
Glutathione S-transferases (GSTs) are a large multigen family of multifunctional enzymes, which play an important role in detoxification of potentially genotoxic chemicals, by catalyzing the conjugation of glutathione to a large number of hydrophobic and electrophilic compounds, including carcinogens. They also bind to a variety of nonsubstrate ligands. The GSTs are widely distributed in mammalian species and can be grouped into four classes, based on their biochemical, immunological and structural properties: alpha, mu, pi and theta.

GSTs are dimeric, mainly cytosolic, enzymes that have extensive ligand binding properties in addition to their catalytic role in detoxification. A separate microsomal class of GSTs exists which is quite distinct from the cytosolic GSTs, and is designated as "membrane-associated proteins in eicosanoid and glutathione metabolism" (MAPEG). The N-terminal region tends to be better conserved within classes as it includes an important part of the active site.GSTs are believed to play a role in cancer prevention, as the electrophilic compounds that are conjugated to glutathione could otherwise react with and modify cellular components such as DNA, thereby initiating carcinogenesis. On the other hand, GSTs might detoxify chemotherapeutic drugs in cancer cells, thus contributing to drug resistance.
In summary, GSTs are a group of enzymes which are centrally involved in drug metabolism and detoxification. Because of their role in detoxification, they have been implicated in drug sensitivity and resistance. They may also influence mutagenesis and carcinogenesis and thus, increased GST activity may become a useful cancer marker.
Since many GST genes are polymorphic, there has been considerable interest in determining whether particular allelic variants are also associated with an increase of risk for certain diseases.

Glutathione S-transferase-Pi
The GST-Pi class (phase II detoxification enzymes) is the most abundant of the human glutathione S-transferases family, a major group of detoxification enzymes and widely distributed in the human body.
In normal human tissues, the enzymes protect cells against reactions with glutathione and reactive oxygen species by reducing organic hydroperoxides via gluthathione peroxidase activity.
The role of GST-Pi in tumor growth and progression is less well known. It is reported to be variably expressed in breast cancer and is associated with estrogen receptor levels expressed by the tumor. Down-regulation of GST-Pi activity in a study done on a T cell line appears to favor apoptosis and inhibition of GST-Pi function induces apoptosis in rat hepatoma cells.
The importance in cancer research is clear, as GST-Pi has been implicated in protection against apoptosis and also suggested to have a role in jun kinase inhibition.
The majority of human tumor cell lines express significant amounts of class pi GST, which is why it is being investigated as a potential marker for various types of cancer. GST-Pi is thought to be associated with increased resistance to anticancer drugs. GST-Pi expression is under investigation as a prognostic indicator for resistance to chemotherapy and a marker of treatment resistance.
Product Image-10748-826

Anti-ATP11A Rabbit Polyclonal Antibody

Catalog Number: (10748-826)
Supplier: Prosci
Description: ATP11A Antibody: ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
Image Unavailable-CH08873-100MG

N-L-Lysyl-L-glutamic acid

Catalog Number: (CH08873-100MG)
Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: N-L-Lysyl-L-glutamic acid is a versatile amino acid derivative that plays a significant role in various biochemical applications. This compound is recognized for its unique structure, which combines the properties of lysine and glutamic acid, making it an essential building block in peptide synthesis and protein engineering. Researchers and industry professionals utilize N-L-Lysyl-L-glutamic acid in the development of pharmaceuticals, particularly in the formulation of peptide-based drugs and as a stabilizing agent in protein formulations. Its ability to enhance solubility and bioavailability makes it a valuable component in drug delivery systems. In addition to its pharmaceutical applications, N-L-Lysyl-L-glutamic acid is also employed in the fields of biotechnology and nutrition. It serves as a key ingredient in dietary supplements aimed at improving muscle recovery and overall health. The compound's unique properties allow for improved interaction with cellular receptors, potentially leading to enhanced therapeutic effects. With its broad range of applications and benefits, N-L-Lysyl-L-glutamic acid stands out as a critical component for researchers and professionals seeking innovative solutions in their respective fields.

New Product


Product Image-89177-044

CentriVap® micro IR Vacuum Concentrator, Labconco

Catalog Number: (89177-044)
Supplier: Labconco
Description: With the smallest footprint available, the new CentriVap® micro IR Vacuum Concentrator fits in tight spaces and is ideal for small throughput in molecular biology, proteomics, genomics, genetics, cell biology and drug discovery labs

Product available on GSA Advantage®


Image Unavailable-76118-028

Anti-CYP2W1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76118-028)
Supplier: Bioss
Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
Image Unavailable-102990-068

Heptenophos ≥98% (by HPLC)

Supplier: Adipogen
Description: Synthetic insecticides derived from phosphoric acid, and capable of disrupting neurotransmission in insects and vertebrates. Ectoparasitocidal drug that works as an acetylcholine esterase inhibitor in arthropods. Compound can be used as analytical reference material.

Product Image-10052-600

Hemostat Blood, Bovine, Citrated, Hardy Diagnostics

Catalog Number: (10052-600)
Supplier: Hardy Diagnostics
Description: Blood, bovine, citrated, screw cap

Product available on GSA Advantage®


Product Image-101189-672

Human Recombinant Lipophilin-A (from E. coli)

Catalog Number: (101189-672)
Supplier: BioVendor
Description: Secretoglobin Family 1D Member 1 binds androgens and other steroids. It also binds chemotherapeutic drugs during the prostate cancer treatment. Steroid hormones regulate its transription. It is secreted into extracellular space.
Image Unavailable-10456-312

Anti-ORM1 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10456-312)
Supplier: Bioss
Description: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Image Unavailable-75784-052

Succinimidyl ester methylene blue DNA/RNA binding dye

Catalog Number: (75784-052)
Supplier: Biotium
Description: The amine reactive succinimidyl ester of MB (methylene blue) can be conjugated to peptides, proteins, drugs, polymeric materials and biomolecules with primary amine groups. The conjugate will have a blue color and be able to complex with nucleic acids. Methylene blue is a well known redox dye which can be reversibly reduced to its colorless leuco form. Upon oxidation, the blue color of the dye is recovered.

SDS


Image Unavailable-10390-112

Anti-ADCY8 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10390-112)
Supplier: Bioss
Description: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).
Image Unavailable-103010-366

AnaTag™ AMCA - X Protein Labeling Kit *Ultra Convenient*, Anaspec

Catalog Number: (103010-366)
Supplier: Anaspec Inc
Description: AMCA-X, SE is one of the most popular blue fluorescent tagging molecules. It is widely used to label antibodies, proteins and small drug molecules. AMCA-X succinimidyl ester contains a seven-atom aminohexanoyl spacer between the fluorophore and the reactive group.
Image Unavailable-76330-532

MAbPac™ Reversed Phase HPLC Column

Catalog Number: (76330-532)
Supplier: Thermo Scientific
Description: MAbPac™ Reversed Phase columns for high-performance reversed-phase (RP) HPLC and LC/MS characterisation of monoclonal antibodies (mAbs), fragments, variants, antibody drug conjugates (ADCs), PEGylated proteins, and bispecific proteins.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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