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Catalog Number: (10104-578)
Supplier: Prosci
Description: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.


Catalog Number: (75931-982)
Supplier: Rockland Immunochemical
Description: SLC29A1 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2). SLC29A1 is a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium (3). As a nucleoside transporter, SLC29A1 plays an important role in the uptake of nucleoside-based anti-cancer drugs; polymorphisms of point mutations in the gene encoding this protein may affect the efficacy of these drugs (4).


Supplier: Bachem Americas
Description: These dipeptides may potentially serve as drug carriers to facilitate diffusion across the blood-brain barrier. Both peptides well permeate through gastro-intestinal lipid membranes, the acidic molecule permeating slower than the ester derivative. As their peptide bonds are stable, both dipeptides are suitable for oral administration.

Supplier: Healthcare Products
Description: Ideal for disinfecting high risk areas endemic with multi-drug resistant organisms, <i>Clostridium</i>, difficile spores, and Norovirus.

Catalog Number: (10802-536)
Supplier: Rockland Immunochemical
Description: The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse. Levels of DAT protein expression are altered by chronic drug administration. It has been shown that phosphorylation at Thr53 directly affects dopamine influx and amphetamine-stimulated substrate efflux, indicating that the Thr53 residue plays a major role in transport activity. Dopamine pT53 Antibody is ideal for researchers interested in neuroscience research.


Supplier: Thermo Scientific Chemicals
Description: Reagent in analytical chemistry, drugs, textile dying, preserving meats, foam rubbers, vinyl plastics
Supplier: Bachem Americas
Description: Eptifibatide, a RGD mimetic, is a glycoprotein (GP) IIb/IIIa receptor antagonist. Clinically, the peptide is used as an antiplatelet drug in combination with heparin and aspirin in the management of unstable angina and in patients undergoing coronary angioplasty and stenting procedures. CAS Number (eptifibatide acetate): 148031-34-9. Offered under Bolar Exemption: All APIs that are sold for development of drug products still patent protected are offered under Bolar Exemption only. The following disclaimer applies: These products are offered and sold in small quantities only and solely for uses reasonably related to privileged trials and studies for obtaining marketing authorization required by law (Bolar Exemption). Bachem cannot be made liable for any infringement of intellectual property rights. It is the sole and only responsibility of the purchaser or user of these products to comply with the relevant national rules and regulations.

Catalog Number: (76079-628)
Supplier: Bioss
Description: Cytochrome P450 4A22 (CYP4A22) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.


Catalog Number: (10109-330)
Supplier: Prosci
Description: FMO3 is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. It acts on TMA to produce TMA-N-oxide.


Catalog Number: (10306-782)
Supplier: Bioss
Description: MRP5 (190-200 kDa) is closely related to MRP4, both lacking the first five membrane spanning regions. MRP5 is a GS-X multi specific organic anion pump (nucleotide analogs). MRP5 may transport DNP-GS and may be inhibited by certain inhibitors of organic anion transport (sulfinpyrazone). MRP5 may also transport organic anions with the anionic moiety of phosphate/phosphonate group, a function which provides the ability to resist against anti cancer drugs 6-MP and thioguanine as well as the anti-HIV drug PMEA.


Catalog Number: (75878-160)
Supplier: BIOASSAY SYSTEMS
Description: For quantitative determination of phospholipid and evaluation of drug effects on its metabolism.

Supplier: Spectrum Chemicals
Description: Dimethylpolysiloxane, Technical, also known as polydimethylsiloxane, is a silicon-based surfactant used in defoamers for over-the-counter drugs and personal care products.
Supplier: AGILENT TECHNOLOGIES, INC (CSD)
Description: Improved inertness and exceptionally low bleed, with great peak shapes for challenging active analytes such as pesticides and drugs of abuse.

Catalog Number: (89177-044)
Supplier: Labconco
Description: With the smallest footprint available, the new CentriVap® micro IR Vacuum Concentrator fits in tight spaces and is ideal for small throughput in molecular biology, proteomics, genomics, genetics, cell biology and drug discovery labs

Product available on GSA Advantage®


Supplier: O&M HALYARD, INC
Description: Gear up for the fight now because there is no safe level of exposure to cytotoxic chemotherapy drugs for healthcare workers.

Supplier: Thermo Fisher Scientific
Description: These high-density plates are designed for a variety of high throughput screening applications and drug discovery.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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