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Catalog Number: (76731-330)

Supplier: ANTIBODIES.COM LLC

Description: Poly (ADP-Ribose) Polymer ELISA kit is a competitive Enzyme-Linked Immunosorbent Assay (cELISA) designed for the <i>in vitro</i> quantitative determination of Poly (ADP-Ribose) Polymer in serum, plasma, tissue homogenates, and other biological fluids.

Catalog Number: (75789-950)

Supplier: Prosci

Description: Ribose-Phosphate Pyrophosphokinase 2 (PRPS2) is a phosphoribosyl pyrophosphate synthetase that belongs to the ribose-phosphate pyrophosphokinase family. PRPS2 is a homodimer. The active form is probably an hexamer composed of three homodimers. PRPS2 catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. PRPS2 catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. In addition, PRPS2 plays a central role in the synthesis of purines and pyrimidines.

Catalog Number: (75793-118)

Supplier: Prosci

Description: Processes such as transcription, repair and replication that require efficient DNA recognition are dependent on modulation of chromatin structure. Chromatin relaxation is a critical event that occurs during DNA repair and is associated with the negatively charged polymer of adenosine 5'-diphosphate (ADP)-ribose (PAR). PAR is synthesized from nicotinamide adenine dinucleotide (NAD+) by the poly(ADP-ribose) polymerase protein family (PARPs), of which PARP-1 (and to a lesser extent PARP-2) respond to DNA-strand breaks. PARP-1 is selectively activated by DNA strand breaks to catalyze the addition of long branched chains of PAR to a variety of nuclear proteins, most notably PARP itself. The amount of PAR formed in living cells with DNA damage is commensurate with the extent of the damage. Under DNA damage conditions, PAR undergoes a rapid turnover, with a half-life in the range of minutes, as PAR is rapidly hydrolyzed and converted to free ADP-ribose by the enzyme poly(ADP-ribose)glycohydrolase (PARG). PAR regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These include transcriptional regulation, cell division, intracellular trafficking, inflammation and energy metabolism.

Catalog Number: (77517-034)

Supplier: AFG Bioscience

Description: Rat cADPRH (Cyclic ADP Ribose Hydrolase) ELISA Kit

Catalog Number: (76482-092)

Supplier: AAT BIOQUEST INC

Description: Z-DEVD-pNA is a colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Catalog Number: (77438-718)

Supplier: Bioss

Description: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

Catalog Number: (76484-674)

Supplier: AAT BIOQUEST INC

Description: This cADP-ribose assay can be performed in a convenient 96-well or 384-well microtiter plate.

Catalog Number: (80059-092)

Supplier: MilliporeSigma

Description: Potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50=40nM).

Supplier: Adipogen

Description: Processes such as transcription, repair and replication that require efficient DNA recognition are dependent on modulation of chromatin structure. Chromatin relaxation is a critical event that occurs during DNA repair and is associated with the negatively charged polymer of adenosine 5'-diphosphate (ADP)-ribose (PAR). PAR is synthesized from nicotinamide adenine dinucleotide (NAD+) by the poly(ADP-ribose) polymerase protein family (PARPs), of which PARP-1 (and to a lesser extent PARP-2) respond to DNA-strand breaks. PARP-1 is selectively activated by DNA strand breaks to catalyze the addition of long branched chains of PAR to a variety of nuclear proteins, most notably PARP itself. The amount of PAR formed in living cells with DNA damage is commensurate with the extent of the damage. Under DNA damage conditions, PAR undergoes a rapid turnover, with a half-life in the range of minutes, as PAR is rapidly hydrolyzed and converted to free ADP-ribose by the enzyme poly(ADP-ribose)glycohydrolase (PARG). PAR regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These include transcriptional regulation, cell division, intracellular trafficking, inflammation and energy metabolism.

Catalog Number: (76707-914)

Supplier: AFG Bioscience

Description: Human Poly ADP Ribose Polymerase (PARP ) ELISA Kit

Catalog Number: (76710-098)

Supplier: AFG Bioscience

Description: Rat Poly ADP-ribose Polymerase 1(PARP1) ELISA Kit

Catalog Number: (89348-552)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to PARP (poly (ADP-ribose) polymerase 1)

Supplier: Ambeed

Description: (2R,3S)-2-(Hydroxymethyl)-5-methoxytetrahydrofuran-3-ol, Purity: 95%, CAS Number: 60134-26-1, Appearance: Colorless to yellow liquid, Storage: Inert atmosphere, Room Temperature, Size: 100g

Catalog Number: (76010-258)

Supplier: Prosci

Description: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

Catalog Number: (89364-994)

Supplier: Genetex

Description: Poly(ADP-ribose) polymerase 1, (PARP-1) and poly(ADP-ribose) polymerase 2 (PARP-2) catalyze the formation of poly(ADP-ribose) polymers in a DNA-dependent manner. PARP-2 displays automodification properties similar to PARP-1. These act by poly(ADP-ribosylation), which is a post-translational modification of nuclear proteins in response to DNA damage that activates the base excision repair machinery.

Supplier: MORAVEK BIOCHEMICALS MS

Description: Phenol, [14C(U)] ≥97% (by HPLC)