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Product Image-10030-470

Biopsy Cassettes, FastLoad Taped Stacks, Closed Lid, Azer Scientific

Supplier: VWR International
Description: FastLoad Biopsy Taped Cassettes feature a recessed hinged lid that can be opened and closed as often as necessary and always relocks securely.

Product available on GSA Advantage®

Image Unavailable-10350-766

Anti-BTK Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10350-766)
Supplier: Bioss
Description: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Product Image-10352-856

Anti-BTK Rabbit Polyclonal Antibody

Catalog Number: (10352-856)
Supplier: Bioss
Description: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Image Unavailable-76083-336

Anti-Btk Ser180 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76083-336)
Supplier: Bioss
Description: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Image Unavailable-MFLX40330-19

Masterflex® 1½ Sanitary Tri-Clamp Cap", Avantor®

Supplier: VWR International
Description: Close off your sanitary fluid line with a secure connection.

Certificates

Product Image-89097-270

Coupling Clamp, Stainless Steel, Circulator Hose, Ace Glass Incorporated

Supplier: Ace Glass
Description: This stainless steel coupling clamp is designed for use with ACE jacketed glass pilot plant reactors and circulator hoses for popular circulating chillers

Small Business Enterprise

Product Image-89078-214

Bath Oil, Ace Glass

Supplier: Ace Glass
Description: An extremely stable, medium viscosity silicone heating bath oil

Small Business Enterprise Product available on GSA Advantage®

Product Image-76333-636

Heavy Duty Cart, For use with Huber Unistat models 405 and 705 Circulators, Chemglass

Catalog Number: (76333-636)
Supplier: Chemglass
Description: Heavy duty cart for use with huber unistat models 405 and 705 circulators.
Product Image-CFA103130-A

VWR® Contour™ Knee Space Filler Panels

Supplier: VWR International
Description: Designed to close off the space between the floor and the bottom of sitting- or standing-height aprons

Product available on GSA Advantage®

Product Image-MFLX98305-26

Masterflex® Particle Tolerant Solenoid Valves, Avantor®

Supplier: VWR International
Description: Particles will not cause damage.

Product Image-10767-798

Circulator Adapters, Beaded Pipe to Male Adapter, Stainless Steel, Pilot Plant, Ace Glass Incorporated

Supplier: Ace Glass
Description: These stainless steel adapters are designed for use with Ace jacketed glass pilot plant reactors and circulator hoses for popular circulating chilllers.

Small Business Enterprise

Image Unavailable-13307-196

Accessories for Precision® Coliform/Fecal Coliform Heated Circulating Water Baths/Incubators, Thermo Scientific

Supplier: Thermo Fisher Scientific
Description: For Coliform/Fecal Coliform Circulating Water Bath/Incubators 13491-000, -002, -004, and -006.

Image Unavailable-10154-368

Accessories for Shaking Baths, Aqua Pro Series, Grant Instruments

Catalog Number: (10154-368)
Supplier: GRANT USA INC.
Description: Water cooling coil. Fits under OLS26 US haking tray. Attach to a water supply or refrigerated circulator. Can be used down to 2 C above the temperature of the coolantHeat exchange coil for OLS26 (connect to cold water supply or refrigerated circulator)
Product Image-MFLX98306-00

Masterflex® Solenoid-Operated Pinch Valve For Masterflex® Pump Tubing, Avantor®

Supplier: VWR International
Description: Specifically designed for Masterflex® pump tubing.

Product Image-16650-049

VWR® Adjustable Spray Wash Bottle

Catalog Number: (16650-049)
Supplier: VWR International
Description: This double-headed wash bottle has an adjustable-spray stream and will keep contents completely free of contaminants if the sprayer and side-fill opening are in the closed position.
Product Image-MFLX98305-10

Masterflex® Solenoid-Operated Pinch Valves for Metric Tubing, Avantor®

Supplier: VWR International
Description: Excellent choice for viscous fluids.

Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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