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Image Unavailable-75842-076

Anti-CD8a Mouse Monoclonal Antibody (BG Violet 450) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Catalog Number: 75842-076
Supplier: BIOGEMS INTERNATIONAL INC.
Product Image-10749-320

Anti-TNFRSF6B Rabbit Polyclonal Antibody

Description: DcR3 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
Catalog Number: 10749-320
Supplier: Prosci
Product Image-89415-340

Anti-DCR3 Rabbit Polyclonal Antibody

Description: DcR3 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
Catalog Number: 89415-340
Supplier: Prosci
Image Unavailable-10766-510

Anti-CD8A Mouse Monoclonal Antibody (PE (Phycoerythrin)-Cy7®) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8 alpha is a member of the Ig superfamily, expressed as a homodimer (CD8 alpha alpha) or as a heterodimer (CD8 alpha beta). CD8+ alpha beta T lymphocytes express both CD8 alpha alpha and CD8 alpha beta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Catalog Number: 10766-510
Supplier: Prosci
Image Unavailable-10766-498

Anti-CD8A Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8 alpha is a member of the Ig superfamily, expressed as a homodimer (CD8 alpha alpha) or as a heterodimer (CD8 alpha beta). CD8+ alpha beta T lymphocytes express both CD8 alpha alpha and CD8 alpha beta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Catalog Number: 10766-498
Supplier: Prosci
Image Unavailable-10766-564

Anti-CD8A Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8 alpha is a member of the Ig superfamily, expressed as a homodimer (CD8 alpha alpha) or as a heterodimer (CD8 alpha beta). CD8+ alpha beta T lymphocytes express both CD8 alpha alpha and CD8 alpha beta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Catalog Number: 10766-564
Supplier: Prosci
Product Image-75932-016

Anti-SLPI Rabbit Polyclonal Antibody

Description: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Catalog Number: 75932-016
Supplier: Rockland Immunochemical
Product Image-75932-018

Anti-SLPI Rabbit Polyclonal Antibody

Description: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Catalog Number: 75932-018
Supplier: Rockland Immunochemical
Image Unavailable-10259-168

Anti-RCAN3 Rabbit Polyclonal Antibody

Description: Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.
Catalog Number: 10259-168
Supplier: Bioss
Image Unavailable-10766-504

Anti-CD8A Mouse Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5®.5) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8 alpha is a member of the Ig superfamily, expressed as a homodimer (CD8 alpha alpha) or as a heterodimer (CD8 alpha beta). CD8+ alpha beta T lymphocytes express both CD8 alpha alpha and CD8 alpha beta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Catalog Number: 10766-504
Supplier: Prosci
Image Unavailable-10453-950

Anti-APIP Rabbit Polyclonal Antibody (Cy7®)

Description: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Catalog Number: 10453-950
Supplier: Bioss
Image Unavailable-10453-954

Anti-APIP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Description: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Catalog Number: 10453-954
Supplier: Bioss
Image Unavailable-10766-506

Anti-CD8A Mouse Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5®.5) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8 alpha is a member of the Ig superfamily, expressed as a homodimer (CD8 alpha alpha) or as a heterodimer (CD8 alpha beta). CD8+ alpha beta T lymphocytes express both CD8 alpha alpha and CD8 alpha beta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Catalog Number: 10766-506
Supplier: Prosci
Image Unavailable-75842-088

Anti-CD8a Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.
Catalog Number: 75842-088
Supplier: BIOGEMS INTERNATIONAL INC.
Image Unavailable-75842-094

Anti-CD8a Mouse Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.
Catalog Number: 75842-094
Supplier: BIOGEMS INTERNATIONAL INC.
Image Unavailable-75842-086

Anti-CD8a Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: OKT8]

Description: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.
Catalog Number: 75842-086
Supplier: BIOGEMS INTERNATIONAL INC.
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