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Supplier: Biotium

Description: CD31 / PECAM-1 Monoclonal antibody, Clone: C31.10, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Immunogen: Recombinant human CD31 protein, Isotype: IgG1, kappa, Synonyms:EndoCAM; PECA1, GPIIA, Application: IF, IHC (formalin), FC, Size: 500 uL

Catalog Number: (75895-990)

Supplier: Biotium

Description: CD43 Monoclonal antibody, Clone: DF-T1, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: BSA-free, Immunogen: Myeloblastic KG1 cells, Synonyms: GALGP, GPL115, Application: IF, IHC, FC, Size: 50 uL

Supplier: Biotium

Description: IgM Immunoglobulin, Monoclonal antibody, Clone: IM260 + ICO-30, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Heavy chain of human IgM, Synonyms: IGHM; Constant Region of Heavy Chain of IgM, Application: IF, Size: 500uL

Supplier: Biotium

Description: This antibody recognizes a 70 kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP This antibody recognizes germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

Description: FOXP3 Monoclonal antibody, Clone: 3G3, Host: Mouse, Species reactivity: Mouse, Monkey, Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Full-length His-tagged mouse FOXP3 protein, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Description: Cytotoxic T lymphocytes (CTLs) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.

Supplier: Biotium

Description: This antibody recognizes a protein of 30-33 kDa, which is identified as CD20 (Workshop V; Code CD20.12. Workshop IV; Code B17). It This antibody recognizes an extracellular domain of CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: PAX7, Monoclonal antibody, Clone: PAX7/1187, Host: Mouse, Species reactivity: Mouse, Zebrafish, Rat, Human, Chicken, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Recombinant fragment (aa300-600) of human PAX7 protein, Synonyms: Paired box gene 7, Size: 500uL

Supplier: Biotium

Description: The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

Supplier: Biotium

Description: This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family. C-erbB-2/HER-2 is a member of the EGFR family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: (75976-640)

Supplier: Biotium

Description: TNF alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha causes cytolysis of certain transformed cells. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Supplier: Biotium

Description: This antibody recognizes a protein of 30-33 kDa, which is identified as CD20 (Workshop V; Code CD20.4). It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.

Supplier: Biotium

Description: CD36 Monoclonal antibody, Clone: 185-1G2, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF594, Immunogen: Stimulated human leukocytesUnigene 120949, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Description: Cytokeratin 8 Monoclonal antibody, Clone: B22.1, Host: Mouse, Species reactivity: Rabbit, Pig, Cow, Sheep, Human, Isotype: IgG, K, Conjugate: CF568, Immunogen: Cytoskeletal preparation, Synonyms: CYK8, CYKER, Cytokeratin Endo A, Application: IF, Size: 100uL

Supplier: Biotium

Description: Complement C4d Monoclonal antibody, Clone: C4D205, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: CF640R, Immunogen: Recombinant human Complement 4d proteinUnigene 534847 & 720022, Application: Immunofluorescence, Size: 100uL

Supplier: Biotium

Description: P21 / WAF1, Monoclonal antibody, Clone: CIP1/823 + DCS-60.2, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: purified, Immunogen: Recombinant full-length human CDKN1A protein (CIP1/823); Human recombinant p21 protein (DCS-60.2), Application: IF, Size: 100uL