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Catalog Number: (10782-380)
Supplier: Biosensis
Description: FUNCTION: Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death. Isoform 2 and isoform 3 may act as decoy receptors. SUBUNIT: Associates with TRAF1, TRAF2, TRAF3 and TRAF5. SUBCELLULAR LOCATION: Isoform 1, isoform 3, isoform 4: Cell membrane; single-pass type I membrane protein (Probable). Isoform 2: Secreted protein (Probable). ALTERNATIVE PRODUCTS: 4 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver. SIMILARITY: Contains 3 TNFR-Cys repeats.


Supplier: Biosensis
Description: The Biosensis GDNF RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of GDNF in less than 4 hours in cell culture supernatants, cell lysates, and guinea pig serum only if used as directed. Please refer to the kit protocol for specific use instructions for each substrate application.

Catalog Number: (76545-480)
Supplier: Biosensis
Description: Rabbit anti-neuronal nuclei antigen/Fox3 (NeuN/Fox3) polyclonal antibody (unconjugated), suitable for WB, IHC, ICC.


Catalog Number: (76545-462)
Supplier: Biosensis
Description: Mouse anti-beta-synuclein monoclonal antibody (unconjugated), suitable for WB, IHC-frozen.


Catalog Number: (76545-466)
Supplier: Biosensis
Description: Rabbit anti-pan-synuclein polyclonal antibody (unconjugated), suitable for WB, FC.


Catalog Number: (76333-984)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76333-980)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76333-996)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76334-000)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76334-006)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76334-038)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76334-016)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76333-976)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76334-018)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76334-040)
Supplier: Biosensis
Description: 31472488


Catalog Number: (76264-600)
Supplier: Biosensis
Description: GAP43 is very abundant protein which is found concentrated in neurons. One group discovered it as one of three proteins which becomes unregulated during the regeneration of the toad optic nerve (1). Three GAPs (Growth associated proteins) were discovered, and the number 43 comes from the apparent SDS-PAGE molecular weight of the one named GAP43. The HGNC name for this protein is, not surprisingly, GAP43. Later work showed that GAP43 does not run on SDS-PAGE in a fashion which accurately reflects its molecular weight, and that GAP43 proteins from different species may run at different apparent molecular weights. Partly due to these features GAP43 were independently discovered by several different groups and therefore has several alternate names, such as protein F1, pp46, neuromodulin, neural phosphoprotein B-50 and calmodulin-binding protein P-57. In each case the number reflects the apparent SDS-PAGE molecular weight, and underlines the unusual properties of this molecule. Mammalian GAP43 proteins contains only 226-243 amino acids, and so the real molecular weight is 23.61-25.14 kDa. GAP43 has been extensively studied and is known to be a major protein kinase C substrate and to bind calmodulin avidly. GAP43 is anchored to the plasma membrane by palmitoylation modifications. This antibody reacts with human, rat, mouse and bovine. It is expected that it will work on other mammal tissues due to amino acid sequence similarity.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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