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Slot / Label / Gap Sensor, Nidec Shimpo

Supplier: Nidec Shimpo America
Description: Sensors are able to learn differences between material and gaps, and provide corresponding output.

Product Image-PAV3762

RET Kinase Enzyme System, Promega

Supplier: Promega Corporation
Description: Recombinant human RET (amino acids 658-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. RET gene codes for a transmembrane tyrosine kinase.

Product Image-89201-056

Accessories for VWR® Heated Circulating Baths

Catalog Number: (89201-056)
Supplier: VWR International

Product available on GSA Advantage®


Product Image-76015-132

Type 1 Macro Cuvettes with PTFE Cover, FireFlySci

Supplier: FIREFLYSCI, INC.
Description: The Firefly Type 1 standard 10 mm cell spectroscopy comes in many various lightpaths and materials to fit the exact needs.

Image Unavailable-76083-650

Anti-IRS1 Ser1101 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76083-650)
Supplier: Bioss
Description: Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
Product Image-76016-334

Particle Analysis Flow Cell (Lightpath: 2 mm), Type 77

Catalog Number: (76016-334)
Supplier: FIREFLYSCI, INC.
Description: 2 mm flow through cell that can be used for flow cytometry, particle analysis, liquid chromatography, and many other applications.
Product Image-10107-956

Anti-PCBP1 Rabbit Polyclonal Antibody

Catalog Number: (10107-956)
Supplier: Prosci
Description: PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
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IR Liquid Sandwich Cells, International Crystal Laboratories

Supplier: International Crystal Labs
Description: Sandwich cells can be used to recondition sealed cells, to provide backup or supplemental sealed cells of different pathlengths, or in a demountable cell

Minority or Woman-Owned Business Enterprise

Product Image-89156-496

Neutrophil elastase colorimetric drug discovery kit, Enzo Life Sciences

Catalog Number: (89156-496)
Supplier: Enzo Life Sciences
Description: It is a complete assay system designed to screen inhibitors of neutrophil elastase, providing enough material to perform at least 96 assays. Neutrophil elastase, also known as leukocyte elastase (LE), is a serine protease found in polymorphonuclear neutrophils (PMNs) that functions in inflammation. It can cleave a variety of proteins, including fibrous elastin, collagen, clotting factors, TNF-α, and α1-antichymotrypsin. It has been shown to be taken up by tumor cells and accelerate tumor growth through its degradation of insulin receptor substrate-1 (IRS-1). Because of its potential roles in cancer and inflammatory diseases such as emphysema, cystic fibrosis, and atherosclerosis, it is a target for drug discovery. The kit uses the chromogenic substrate MeOSuc-Ala-Ala-Pro-Val-pNA; cleavage of p-nitroaniline (pNA) from the substrate increases absorbance at 405nm. A neutrophil elastase inhibitor, elastatinal, is included for use as a control.
Image Unavailable-75790-416

Human Recombinant LMIR2 (from Cells)

Catalog Number: (75790-416)
Supplier: Prosci
Description: CD300C is a single-pass type I membrane protein which belongs to the immunoregulatory signaling (IRS) family. CD300C contains one Ig-like V-type domain and is present on the surface of natural killer cells, granulocytes, most myeloid cells, dendritic cells, and a subpopulation of T and B lymphocytes. The CD300C (CMRF-35A) and CD300A (CMRF-35H) molecules are homologous leukocyte surface proteins. CD300a and CD300C play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300A and CD300C are indistinguishable on the surface of NK cells. The ligand for CD300C is presently unknown.
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Anti-IgG Donkey Polyclonal Antibody (CF™ 680)

Supplier: Biotium
Description: This product is prepared by labeling highly cross-adsorbed donkey anti-rabbit IgG (H+L) with our near-IR fluorescent dye CF™680. To minimize cross-reactivity, the antibody has been adsorbed against bovine, chicken, goat, guinea pig, Syrian hamster, horse, human, mouse, rat, and sheep serum proteins. Far red/near-infrared CF™680 (Ex/Em 681/698 nm) is brighter and produces antibody conjugates with the best signal-to-noise ratio compared to other spectrally similar dyes.

Image Unavailable-76449-286

VWR® Aluminium Foil Seals for PCR

Catalog Number: (76449-286)
Supplier: VWR International
Description: Precut aluminum foil seals on a roll for PCR applications. Supplied on a roll with holder for ease of use.
Image Unavailable-10136-228

Rectangular Semi-Demountable Cell Kits, Preassembled, PerkinElmer

Catalog Number: (10136-228)
Supplier: PerkinElmer
Description: The semi-demountable cell can be used either as a demountable cell or as a sealed cell for high-viscosity liquids or mull samples.
Image Unavailable-10233-804

Anti-BAIAP2 Rabbit Polyclonal Antibody

Catalog Number: (10233-804)
Supplier: Bioss
Description: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the end of this gene results in three products of undetermined function.
Image Unavailable-10354-180

Anti-IRS1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10354-180)
Supplier: Bioss
Description: Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
Product Image-89214-722

VWR® Upright Freezer Racks for 15 and 50 ml Centrifuge Tubes, Stainless Steel

Catalog Number: (89214-722)
Supplier: VWR International
Description: Durable stainless steel freezer racks facilitate organization and maximize valuable storage space.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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