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Description: Human T cell activation and expansion reagent. 1×2 ml vial.
Catalog Number: MSPP-10970
Supplier: STEMCELL Technologies


Description: TGF Alpha may be used with the appropriate optimized medium and human epithelial cells.
Catalog Number: 102970-848
Supplier: Lifeline Cell Technology

SDS


Description: StiMel8 may be used with human melanocytes and the appropriate optimized medium.
Catalog Number: 102970-748
Supplier: Lifeline Cell Technology

SDS


Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. .
Catalog Number: 76077-580
Supplier: Bioss


Description: Human Umbilical Cord Tissue Preparation Buffer Primacell* 4, Normal Umbilical Vein Endothelial Cells, 1x100ml
Catalog Number: 10785-260
Supplier: CHI Scientific


Description: PrimaCell* Mouse Artery Tissue Preparation Buffer: Normal Coronary Artery Endothelial Cells, 1 x 100 ml
Catalog Number: 10783-354
Supplier: CHI Scientific


Description: Primacell* 3 Human Cervix Tissue Preparation Buffer 3: Normal Cervical Smooth Muscle Cells, 1 x 100 ml
Catalog Number: 10784-802
Supplier: CHI Scientific


Description: PrimaCell* 1 Human Ureter Tissue Preparation Buffer 1, Normal Lliac Artery Endothelial Cells, 1 x 100 ml
Catalog Number: 10786-860
Supplier: CHI Scientific


Description: Primacell* 4 Human Heart Tissue Preparation Buffer 4: Normal Saphenous Vein Endothelial Cells, 1 x 100 ml
Catalog Number: 10784-962
Supplier: CHI Scientific



Description: The PromoCell Mononuclear Cell Medium is a very rich short-term maintenance medium which provides utmost cell viability
Catalog Number: 10172-392
Supplier: Promocell


Description: Smooth Muscle Cell Growth Medium 2 SupplMix; 1 mix
Catalog Number: 10172-458
Supplier: Promocell


Description: Skeletal Muscle Cell Differentiation Medium SupplMix; 1 mix
Catalog Number: 10172-480
Supplier: Promocell


Description: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Catalog Number: 10236-164
Supplier: Bioss


Description: The FibrOutTM System is a combination of several biochemical compounds and reagents which prevent fibroblastic overgrowth and increase targeted cell growth during primary cell culture
Catalog Number: 10786-020
Supplier: CHI Scientific


Description: The FibrOutTM System is a combination of several biochemical compounds and reagents which prevent fibroblastic overgrowth and increase targeted cell growth during primary cell culture
Catalog Number: 10786-058
Supplier: CHI Scientific


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