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Image Unavailable-10387-650

Anti-H3F3A Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10387-650)
Supplier: Bioss
Description: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Product Image-10393-796

Anti-H3F3A Rabbit Polyclonal Antibody

Catalog Number: (10393-796)
Supplier: Bioss
Description: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Product Image-PAV1771

PI3K (p110delta/p85alpha)

Catalog Number: (PAV1771)
Supplier: Promega Corporation
Description: The PI3K lipid kinase enzymes are used with ADP-Glo KInase Assay System and Lipid Kinase Substrates in a homogeneous, add-mix-read lipid kinase assay.
Image Unavailable-10236-160

Anti-H3F3A Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10236-160)
Supplier: Bioss
Description: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Image Unavailable-10353-780

Anti-H2AFX Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10353-780)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Image Unavailable-10353-774

Anti-H2AFX Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10353-774)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Image Unavailable-76083-618

Anti-Histone H2A.X Ser140 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76083-618)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Product Image-100000-002

ESF 921 Insect Cell Culture Medium

Supplier: Expression Systems
Description: ESF 921™ Insect cell culture medium is a complete serum-free, protein-free medium developed for robust cell growth, protein production and baculovirus vector production for a wide range of insect cells including Sf9, Sf21, Tni (High Five™), and Drosophila S2.

Product Image-89358-724

Anti-ITM2C Rabbit Polyclonal Antibody

Catalog Number: (89358-724)
Supplier: Genetex
Description: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Product Image-89032-118

VWR® Advanced 15000 Orbital Shakers, 230 V

Catalog Number: (89032-118)
Supplier: VWR International
Description: Digital orbital shakers are designed for a wide range of applications such as solubility studies, extraction procedures, and cell cultures that require accurate and reproducible results.

CE Compliant


Product Image-77623-770

VWR® Incubating Mini Shakers, 230 V

Supplier: VWR International
Description: VWR® Incubating mini shakers feature variable-speed, microprocessor control, providing reliable, uniform mixing action with accurate temperature control. Ideal for cell cultures, solubility studies, extraction procedures, diagnostic tests, general mixing, hybridization, genetics research, bacterial suspensions, staining/destaining and washing procedures.

Irregular Voltage New Product

Product Image-76234-926

Anti-HIST1H3A Rabbit Polyclonal Antibody

Catalog Number: (76234-926)
Supplier: Rockland Immunochemical
Description: Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histone proteins are highly post-translationally modified with Histone H3 being the most extensively modified of the five histones. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3 Antibody is ideal for investigators involved in Cell Signaling, Epigenetics, Nuclear Signaling research and Signal Transduction research.
Product Image-76081-552

Biox Culture Dishes

Supplier: TWD Scientific
Description: Sterile and constructed of optically clear material, these cell culture dishes offer high quality at a great price.

Small Business Enterprise Minority or Woman-Owned Business Enterprise

Product Image-PAV4107

ADP-Glo Kinase Assay + DNA-PK Kinase Enzyme System, 1 each, Promega

Catalog Number: (PAV4107)
Supplier: Promega Corporation
Description: Native human DNA-Dependent Protein Kinase purified from HeLa cells. Consists of a ~460kDa catalytic subunit and a heterodimeric DNA-binding subunit (Ku) containing an 85kDa and a 70kDa peptide (1). Gene sequence can be found at accession number NM_006904.

SDS


Product Image-77751-076

Human Recombinant R-SPONDIN-1 (from CHO cells)

Supplier: VWR International
Description: R-Spondin-1 (RSPO-1) is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling. RSPO-1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification. The RSPO-1 stabilization of β-catenin promotes intestinal crypt cell proliferation. This suggests that RSPO-1 functions as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis. Additionally, recombinant RSPO-1 protein is used to initiate and maintain intestinal organoid cultures.

New Product

Image Unavailable-102869-084

Human Recombinant TGF-beta 1 (from HEK293 Cells)

Catalog Number: (102869-084)
Supplier: R&D Systems
Description: The Recombinant Human TGF-beta 1 (Human Cell-expressed) from R&D Systems is derived from HEK293. The Recombinant Human TGF-beta 1 (Human Cell-expressed) has been validated for the following applications: Bioactivity.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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