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Image Unavailable-10431-984

Anti-NET1 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10431-984)
Supplier: Bioss
Description: This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Image Unavailable-10338-534

Anti-ARHGEF2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10338-534)
Supplier: Bioss
Description: GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.
Image Unavailable-10338-536

Anti-ARHGEF2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10338-536)
Supplier: Bioss
Description: GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.
Image Unavailable-10262-708

Anti-RND2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10262-708)
Supplier: Bioss
Description: The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
Image Unavailable-10262-706

Anti-RND2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10262-706)
Supplier: Bioss
Description: The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
Product Image-10101-758

Anti-GABRR2 Rabbit Polyclonal Antibody

Catalog Number: (10101-758)
Supplier: Prosci
Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family and is a component of the GABA receptor complex.GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex.
Product Image-102965-154

96-Well ROCK Activity Assay Kit, Cell Biolabs

Supplier: Cell Biolabs
Description: Cell Biolabs' 96-Well ROCK Activity Assay Kit uses a safe, non-radioactive format to measure the level of active Rho Kinase in cell or tissue lysates

Image Unavailable-10431-968

Anti-NET1 Rabbit Polyclonal Antibody

Catalog Number: (10431-968)
Supplier: Bioss
Description: This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Image Unavailable-10262-704

Anti-RND2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10262-704)
Supplier: Bioss
Description: The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.
Image Unavailable-10402-572

Anti-ARHGAP20 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10402-572)
Supplier: Bioss
Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Image Unavailable-10402-574

Anti-ARHGAP20 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10402-574)
Supplier: Bioss
Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Product Image-89348-666

Anti-RAC1 Rabbit Polyclonal Antibody

Catalog Number: (89348-666)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))
Image Unavailable-10168-062

Anti-ARHGEF18 Mouse Monoclonal Antibody [clone: GT1972]

Catalog Number: (10168-062)
Supplier: Genetex
Description: Mouse Monoclonal antibody [GT1972] to ARHGEF18 (Rho/Rac guanine nucleotide exchange factor (GEF) 18)
Product Image-10100-430

Anti-DAAM1 Rabbit Polyclonal Antibody

Catalog Number: (10100-430)
Supplier: Prosci
Description: Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
Image Unavailable-10452-878

Anti-TIAM1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10452-878)
Supplier: Bioss
Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
Image Unavailable-AAJ63525-MA

Fasudil 98

Catalog Number: (AAJ63525-MA)
Supplier: Thermo Scientific Chemicals
Description: A potent Rho-kinase inhibitor with antivasospastic properties; inhibits vascular smooth muscle contraction by acting as an intracellular calcium antagonist

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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