You Searched For: 15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic+acid+(HETE)


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Supplier: Enzo Life Sciences
Description: Biosynthesis in human neutrophils, eosinophils and reticulocytes. Most abundant eicosanoid in human bronchi. Regulates T lymphocyte mitogenesis. Induces immunosupression. Stimulates migration of capillary endothelial cells and neovascularisation.

Catalog Number: (89160-016)
Supplier: Enzo Life Sciences
Description: Activator of PKC and PPARα.


Catalog Number: (89160-014)
Supplier: Enzo Life Sciences
Description: Biosynthesis via 5-lipoxygenase. Chemotactic and chemokinetic for PMNL. Induces degranulation and calcium flux.


Catalog Number: (76002-378)
Supplier: Enzo Life Sciences
Description: Biosynthesis by platelet 12-lipoxygenase. Chemotactic and chemokinetic for PMNL2 and for vascular smooth muscle cells. Antiproliferative effect on smooth muscle cells. Second messenger in angiotensin induced aldosterone production. Induces endothelial cell retraction and tumor cell adhesion.


Catalog Number: (89160-028)
Supplier: Enzo Life Sciences
Description: Biosynthesis in psoriatic skin and corneal epithelial cells via cytochrome P-450. More potent than 12(S)-HETE in inducing human leukocyte chemokinesis and aggregation. Proinflammatory effects in human skin. Inhibits renal, cardiac and corneal Na+,K+-ATPase. Reduces intraocular pressure.


Catalog Number: (89160-194)
Supplier: Enzo Life Sciences
Description: Biosynthesis via 15-OH prostaglandin dehydrogenase from lung and liver microsomes and by a nonenzymatic process.


Supplier: MilliporeSigma
Description: Precursor for prostaglandins, prostacyclin and thromboxane
Supplier: Ambeed
Description: Arachidonic acid ≥99%

New Product

Supplier: TCI America
Description: CAS Number: 506-32-1
MDL Number: MFCD00004417
Molecular Formula: C20H32O2
Molecular Weight: 304.47
Purity/Analysis Method: >97.0% (GC)
Form: Clear Liquid
Flash Point (°C): 110
Specific Gravity (20/20): 0.92
Storage Temperature: <0°C
Supplier: Enzo Life Sciences
Description: Precursor to a large family of eicosanoids. Acts as a second messenger independent of metabolism. Retrograde messenger in long-term potentiation in the nervous system. Inhibits ras-GAP. Activator for several protein kinase C (PKC) isotypes.
Catalog Number: (89158-428)
Supplier: Enzo Life Sciences
Description: Cannabinoid receptor ligand.


Supplier: MP Biomedicals
Description: An essential fatty acid, and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides.

SDS

Supplier: MP Biomedicals
Description: Arachidonic Acid is an essential fatty acid. Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides.
Arachidonic Acid is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid plays a key role in cellular regulation and is controlled through multiple interconnected pathways.
Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
If ethanol is undesirable, arachidonic acid may be dissolved in acetonitrile, DMF, or DMSO. Simply evaporate the ethanol under a gentle stream of nitrogen (be certain not to evaporate the material to dryness) and redissolve the arachidonic acid in the solvent of choice.Just prior to use, make dilutions of the stock solution into aqueous buffer or isotonic saline to bring the arachidonic acid to the desired concentration. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiologic effects at low concentrations. A control using the solvent in the absence of the prostaglandin will address this potential variable. We do not recommend storing the aqueous solution for more than one day. It is difficult to obtain aqueous solutions of arachidonic acid directly. However, an organic solvent free solution of arachidonic acid can be prepared using concentrated basic buffers (pH > 8.0 and ionic strength not less than 0.1 M). Add 400 μL of cold buffer (0 °C) per mg of arachidonic acid and agitate vigorously and/or ultrasonicate.

Catalog Number: (89160-190)
Supplier: Enzo Life Sciences
Description: R527 ligand.


Catalog Number: (AAJ67423-LB0)
Supplier: Thermo Scientific Chemicals
Description: Liquid

Catalog Number: (89157-312)
Supplier: Enzo Life Sciences
Description: Arachidonic acid metabolite.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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