AS601245 ≥95%, Moligand™
Supplier: ALADDIN SCIENTIFIC CORPORATION
Synonyms:
(Z)-2-(benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)imino)-1,2-dihydropyrimidin-4-yl)acetonitrile, (2Z)-2-(3H-1,3-Benzothiazol-2-ylidene)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile, SAPK Inhibitor V, 2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Product Introduction:A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration. Biochemical mechanism:Cell permeable: yesProduct competes with ATP.Primary TargethJNK 1, hJNK 2, hJNK 3Reversible: yesTarget IC50: 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
Formula:
C₂₀H₁₆N₆S MW: 372.45 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD07772196 CAS Number: 345987-15-7 |
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