Axitinib ≥99%, Moligand™

Supplier: ALADDIN SCIENTIFIC CORPORATION

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Synonyms: AG-013736, (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

A129732-1G A129732-250MG A129732-50MG

ALA129732-1GEA 197.51 USD

ALA129732-1G ALA129732250MG ALA129732-50MG

Axitinib ≥99%, Moligand™

Axitinib

Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β.An inhibitor of Flt and Flk (VEGFR) with antitumor properties

Application:

Axitinib has been used as a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (TKI) to study its effect on renal cancer cell proliferation in vitro. It has also been used to inhibit anterior mesenteric artery (AMA) angiogenesis in dechlorinated embryos maintained in conditioned water (CW).

Formula: C₂₂H₁₈N₄OS
MW: 386.5 g/mol
Storage Temperature: Ambient

MDL Number: MFCD09837898
CAS Number: 319460-85-0

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