IQ-1 ≥95% (by HPLC), Calbiochem®, Sigma-Aldrich®
Supplier: MilliporeSigma
Synonyms:
2-((4-Acetylphenyl)diazenyl)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide, Wnt Pathway Activator III, IQ 1, 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide
M-Clarity™ quality level = MQ100
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.
General description
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.
Envase: Packaged under inert gas
Formula:
C₂₁H₂₂N₄O₂ MW: 362.43 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00354369 CAS Number: 331001-62-8 |
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