IQ-1 ≥95% (by HPLC), Calbiochem®, Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: 2-((4-Acetylphenyl)diazenyl)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide, Wnt Pathway Activator III, IQ 1, 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide

M-Clarity™ quality level = MQ100

412400-10MG 412400-10MG
82603-628EA 326.52 USD
82603-628 82603-168
IQ-1 ≥95% (by HPLC), Calbiochem®, Sigma-Aldrich®
IQ-1

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.


General description
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.


Envase: Packaged under inert gas

Formula: C₂₁H₂₂N₄O₂
MW: 362.43 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00354369
CAS Number: 331001-62-8

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR