Calbiochem® MG-132

Supplier: MilliporeSigma

474790-5MG 474790-1MG
80053-196EA 251.3 USD
80053-196 80053-194
Calbiochem® MG-132
Proteins and Peptides

A potent, reversible, and cell-permeable proteasome inhibitor (Ki=4nM)


Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-[kappa]B activation (IC50=3µM).

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