Nα-(p-Toluenesulfonyl)-DL-lysine chloromethyl ketone hydrochloride, Calbiochem®
Supplier: MilliporeSigma
Inhibits trypsin-like serine proteinases
Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-[gamma] and lipopolysaccharides (EC50=80µM). Prevents endonucleolysis accompanying apoptotic cell death of HL-60 leukemia cells and normal thymocytes.
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