Bovine Thrombin, MP Biomedicals
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Thrombin is prepared from fresh bovine plasma by an ion exchange method
- High Purity Grade
- Concentration: ~10% (Protein)
- Presentation: White Powder
- Plasminogen and plasmin not detected.
α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.
Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.
Fibrinogen is removed from the prothrombin complex by precipitation. The concentrated prothrombin complex is then activated by beef thromboplastin and calcium. The thrombin solution is clarified by centrifugation and filtration and then lyophilized.
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...