Bovine Thrombin, MP Biomedicals

Supplier: MP BIOMEDICALS (FKA ICN BIOMED

0215416301 0215416305 0215416310 0215416350 0215416380
IC15416301EA 112.49 USD
IC15416301 IC15416305 IC15416310 IC15416350 IC15416380
Bovine Thrombin, MP Biomedicals
Enzymes

Thrombin is prepared from fresh bovine plasma by an ion exchange method


  • High Purity Grade
  • Concentration: ~10% (Protein)
  • Presentation: White Powder
  • Plasminogen and plasmin not detected.


α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.


Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.


Fibrinogen is removed from the prothrombin complex by precipitation. The concentrated prothrombin complex is then activated by beef thromboplastin and calcium. The thrombin solution is clarified by centrifugation and filtration and then lyophilized.

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