Sodium cholate ≥98.5%, white powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
3α,7α,12α-Trihydroxy-5β-cholanic acid sodium salt, 3α,7α,12α-Trihydroxycholan-24-oic acid sodium salt, 3α,7α,12α-Trihydroxycholanic acid sodium salt, Sodium 3α,7α,12α-trihydroxy-5β-cholanoate, Sodium 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoate, Cholic acid sodium salt, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid, sodium salt
Cholic acid is a biochemical solubilizing agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.
- Critical Micelle Concentration (CMC): 14mM
Cholic acid is used in the solubilization of membrane-bound proteins in their native state. It is a component for the preparation of liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.
Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Cholic acid is used in the solubilization of membrane-bound proteins in their native state. It is a component for the preparation of liposomes.
Soluble in water (100 mg/ml). Soluble in ethanol (40 mg/ml - clear, colorless solution).
Formula:
C₂₄H₃₉NaO₅ MW: 430.56 g/mol Melting Pt: 198 °C Storage Temperature: Ambient |
MDL Number:
MFCD00150749 CAS Number: 361-09-1 EINECS: 206-643-5 |
Specification Test Results
Identity Test | Passes |
Purity (HPLC) | ≥98.5% |
Loss on Drying | ≤5% |
pH (2% aq soln) | 7.5-9.0 |
Solubility (2% aq soln) | Clear and Colorless |
Sodium Deoxycholate | ≤1.5% |
Heavy Metals | ≤50 ppm |
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