Dexamethasone, white powder, Cell Culture Grade
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Danger
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Synonyms:
Dexamethasonum, 9-Fluor-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadien-3,20-dion
Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils but to inhibit apoptosis in neutrophils.
- Grade : Cell culture reagent
- Suitability : Suitable for Cell Culture
- Key Applications : Anti-inflammatory
- Application Areas : Cell Biology & Analysis
- Product Type : Biochemicals
- Biochemical Category : Pharmaceuticals
- Chemical Class : Pharmaceuticals
- Optical Rotation : (c=1, dioxane)+72 ° to +80 °
- Refractive Index : 76 ° (C=1, Dioxane) (Lit.)
- Presentation : White Powder
- Loss on Drying : ≤0.5%
- Solubility : Slightly soluble in water (10 mg/100 mL), ethanol (1 mg/mL), chloroform; sparingly soluble in acetone, alcohol, dioxane, and methanol; very slightly soluble in ether.
Storage: protect from light.
Formula:
C₂₂H₂₉FO₅ MW: 392.47 g/mol Melting Pt: 262...264 °C (lit.) Storage Temperature: Ambient |
MDL Number:
MFCD00064136 CAS Number: 50-02-2 |
Specification Test Results
Identity Test | Passes |
FTIR | Conforms to Standard |
Loss on Drying | <0.5% |
Optical Rotation |
+72° to +80° (c=1, dioxane) |
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