Hygromycin B (from Streptomyces hygroscopicus), >1000 u/mg ≥95%, white powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Danger
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Synonyms:
(3aS,3'R,4S,4'S,5'R,6R,6'R,7S,7aS)-4-(((1R,2S,3R,5S,6R)-3-Amino-2,6-dihydroxy-5-(methylamino)cyclohexyl)oxy)-6'-((S)-1-amino-2-hydroxyethyl)-6-(hydroxymethyl)octahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetraol
Hygromycin B is an antibiotic substance isolated from Streptomyces hygroscopicus. Its mode of action is the inhibition of protein synthesis, by inducing the misreading of the m-RNA template in the prokaryote, (E. coli, at 100 mg/mL), lower eukaryotes (e.g., yeast, at 200 mg/mL) and higher eukaryotes (e.g., mammalian cells in culture). It selectively penetrates cells that have been rendered permeable by virus infection and combined with its potency to inhibit translation, it is an effective antiviral agent. Hygromycin B can be used as a dual-selection antibiotic when used in conjunction with G418 or Zeocin™ for cells transfected with two different vectors.
- Purity : ~95%
- Specific Activity : >1000 u/mg
- Key Applications : In gene transfer experiments as a selection agent.
- Application Areas : Cell Culture
- Research Areas : Immunology, Cell Biology, Gene expression
- Product Type : Biochemicals
- Biochemical Category : Antibiotics
- Chemical Class : Pharmaceuticals
- Presentation : White Powder
- pKa : 7.1
- Detection Method : FTIR
- Solubility : Freely soluble in water (50 mg/mL), methanol,buffer solution and ethanol. Practically insoluble in less polar solvents.
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Formula:
C₂₀H₃₇N₃O₁₃ MW: 527.5 g/mol Melting Pt: 160...180 °C (lit.) Storage Temperature: Refrigerator |
MDL Number:
MFCD06795479 CAS Number: 31282-04-9 UN: 3462 ADR: ,I |
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Specification Test Results
| Identity Test | Passes |
| Purity | >90% |
| Activity | >1000 u/mg |
| FTIR | Conforms to Reference |
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