Anti-IDH1 Mouse Monoclonal Antibody [clone: IDH1/1152]

Supplier: Biotium

BNUB1152-100 BNUB1152-500

75951-966EA 240.92 USD

75951-966 75951-968

Anti-IDH1 Mouse Monoclonal Antibody [clone: IDH1/1152]

Antibodies

This antibody recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of alpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

Type: Primary
Antigen: IDH1
Clonality: Monoclonal
Clone: Clone IDH1/1152
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 andIgG2a, kappa
Reactivity: Human

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