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Anti-CDw17 Mouse Monoclonal Antibody [clone: HuLy-m13]

Supplier: Biotium

BNUB1088-100 BNUB1088-500

75909-364EA 240.92 USD

75909-364 75909-366

Anti-CDw17 Mouse Monoclonal Antibody [clone: HuLy-m13]

Antibodies

CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19 ) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor alpha (TNFa)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.

Type: Primary
Antigen: CDw17
Clonality: Monoclonal
Clone: Clone HuLy-m13
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgM
Reactivity: Human

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