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Anti-FCGR2A Mouse Monoclonal Antibody [clone: 7.3]

Supplier: Biotium

BNUB1078-100 BNUB1078-500

75892-948EA 240.92 USD

75892-948 75892-950

Anti-FCGR2A Mouse Monoclonal Antibody [clone: 7.3]

Antibodies

This MAb reacts with a CD32 (Fc gamma RII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (Fc gamma RII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

Type: Primary
Antigen: FCGR2A
Clonality: Monoclonal
Clone: Clone 7.3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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