Anti-CD46 Mouse Monoclonal Antibody (Biotin) [clone: 197-2B1]

Supplier: Biotium

BNCB0931-100 BNCB0931-500

75913-662EA 205.77 USD

75913-662 75913-664

Anti-CD46 Mouse Monoclonal Antibody (Biotin) [clone: 197-2B1]

Antibodies

This antibody recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This MAb can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells.

Type: Primary
Antigen: CD46
Clonality: Monoclonal
Clone: Clone 197-2B1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human

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