Anti-CD46 Mouse Monoclonal Antibody (Biotin) [clone: 169-1-E4.3]

Supplier: Biotium

BNCB0930-100 BNCB0930-500

75913-586EA 205.77 USD

75913-586 75913-588

Anti-CD46 Mouse Monoclonal Antibody (Biotin) [clone: 169-1-E4.3]

Antibodies

This antibody recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Type: Primary
Antigen: CD46
Clonality: Monoclonal
Clone: Clone 169-1-E4.3
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Baboon, Human

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