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Anti-GPC3 Mouse Monoclonal Antibody (Biotin) [clone: 1G12]

Supplier: Biotium

BNCB0862-100 BNCB0862-500

75926-928EA 205.77 USD

75926-928 75926-930

Anti-GPC3 Mouse Monoclonal Antibody (Biotin) [clone: 1G12]

Antibodies

This antibody recognizes a protein, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

Type: Primary
Antigen: GPC3
Clonality: Monoclonal
Clone: Clone 1G12
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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