Anti-IVL Mouse Monoclonal Antibody (CF680) [clone: IVRN/827]

Supplier: Biotium

BNC800827-100 BNC800827-500
75955-108EA 205.77 USD
75955-108 75955-110
Anti-IVL Mouse Monoclonal Antibody (CF680) [clone: IVRN/827]
Antibodies
This antibody recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®680 is a near-infrared fluorescent dye (Ex/Em 681/698 nm). It yields the brightest conjugates among spectrally similar dyes, and is validated in super-resolution imaging by STORM.

Type: Primary
Antigen: IVL
Clonality: Monoclonal
Clone: Clone IVRN/827
Conjugation: CF680
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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