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Anti-TNF Mouse Monoclonal Antibody [clone: TNF706 P/T2]

Supplier: Biotium

BNUB0707-100 BNUB0707-500

75977-138EA 240.92 USD

75977-138 75977-140

Anti-TNF Mouse Monoclonal Antibody [clone: TNF706 P/T2]

Antibodies

TNF alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha causes cytolysis of certain transformed cells. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Type: Primary
Antigen: TNF
Clonality: Monoclonal
Clone: Clone TNF706 P/T2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgM kappa
Reactivity: Cat, Dog, Human, Mouse, Rabbit, Rat, Zebrafish

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