Anti-BCL2 Mouse Monoclonal Antibody (CF594) [clone: 124]

Supplier: Biotium

BNC940530-100 BNC940530-500

75884-678EA 205.77 USD

75884-678 75884-680

Anti-BCL2 Mouse Monoclonal Antibody (CF594) [clone: 124]

Antibodies

This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: BCL2
Clonality: Monoclonal
Clone: Clone 124
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human

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