Anti-BCL2 Mouse Monoclonal Antibody (CF640R) [clone: 124]

Supplier: Biotium

BNC400530-100 BNC400530-500

75884-682EA 205.77 USD

75884-682 75884-684

Anti-BCL2 Mouse Monoclonal Antibody (CF640R) [clone: 124]

Antibodies

This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: BCL2
Clonality: Monoclonal
Clone: Clone 124
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human

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