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Anti-CD7 Mouse Monoclonal Antibody (Biotin) [clone: C7/511]

Supplier: Biotium

BNCB0511-100 BNCB0511-500

75917-782EA 205.77 USD

75917-782 75917-784

Anti-CD7 Mouse Monoclonal Antibody (Biotin) [clone: C7/511]

Antibodies

This antibody recognizes a protein of 40 kDa, identified as CD7, a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Type: Primary
Antigen: CD7
Clonality: Monoclonal
Clone: Clone C7/511
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human

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