Anti-SUMO1 Mouse Monoclonal Antibody [clone: SM1/495]

Supplier: Biotium

BNUB0495-100 BNUB0495-500

75974-422EA 240.92 USD

75974-422 75974-424

Anti-SUMO1 Mouse Monoclonal Antibody [clone: SM1/495]

Antibodies

This MAb is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane.

Type: Primary
Antigen: SUMO1
Clonality: Monoclonal
Clone: Clone SM1/495
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Rat

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