Anti-CTNNB1 Rabbit Polyclonal Antibody (CF640R)

Supplier: Biotium

BNC400376-100 BNC400376-500
75980-396EA 205.77 USD
75980-396 75980-398
Anti-CTNNB1 Rabbit Polyclonal Antibody (CF640R)
Antibodies
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: CTNNB1
Clonality: Polyclonal
Clone:
Conjugation: CF640R
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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