Anti-MVP Mouse Monoclonal Antibody (CF488A) [clone: 1032]

Supplier: Biotium

BNC880225-100 BNC880225-500
75964-496EA 205.77 USD
75964-496 75964-498
Anti-MVP Mouse Monoclonal Antibody (CF488A) [clone: 1032]
Antibodies
This antibody recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: MVP
Clonality: Monoclonal
Clone: Clone 1032
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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