Anti-CD55 Mouse Monoclonal Antibody [clone: 143-30]

Supplier: Biotium

BNUB0179-100 BNUB0179-500

75914-496EA 240.92 USD

75914-496 75914-498

Anti-CD55 Mouse Monoclonal Antibody [clone: 143-30]

Antibodies

This antibody recognizes a single chain glycoprotein of 70 kDa, identified as CD55 (also known as decay accelerating factor, DAF). CD55/DAF is widely expressed on cells throughout the body including leukocytes, erythrocytes, epithelium, endothelium, and fibroblasts. It is a Glycosyl phosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. It prevents the amplification steps of the complement cascade by interfering with the assembly of the C3-convertases, C4b2a and C3bBb, and the C5-convertase, C4b2a3b and C3bBb3b. CD55 also serves as receptor for CD97 and for echovirus and Coxsackie B virus. The MAb 143-30 can be used as marker for paroxysmal nocturnal hemoglobinuria (PNH).

Type: Primary
Antigen: CD55
Clonality: Monoclonal
Clone: Clone 143-30
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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