Anti-CD33 Mouse Monoclonal Antibody (CF488A) [clone: WM53]

Supplier: Biotium

BNC880166-100 BNC880166-500
75894-210EA 205.77 USD
75894-210 75894-212
Anti-CD33 Mouse Monoclonal Antibody (CF488A) [clone: WM53]
Antibodies
This antibody recognizes a 67 kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: CD33
Clonality: Monoclonal
Clone: Clone WM53
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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