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Anti-B2M Mouse Monoclonal Antibody [clone: BBM.1]

Supplier: Biotium

BNUB0142-100 BNUB0142-500

75882-140EA 240.92 USD

75882-140 75882-142

Anti-B2M Mouse Monoclonal Antibody [clone: BBM.1]

Antibodies

This antibody recognizes a protein of 12 kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Type: Primary
Antigen: B2M
Clonality: Monoclonal
Clone: Clone BBM.1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human, Non-human primates

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