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Anti-CD33 Mouse Monoclonal Antibody (Biotin) [clone: C33/68]

Supplier: Biotium

BNCB0068-100 BNCB0068-500

75894-030EA 205.77 USD

75894-030 75894-032

Anti-CD33 Mouse Monoclonal Antibody (Biotin) [clone: C33/68]

Antibodies

This antibody recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Type: Primary
Antigen: CD33
Clonality: Monoclonal
Clone: Clone C33/68
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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