Silylation Reagents

Supplier: Thermo Scientific

TS-48910 TS-48911 TS-48913 TS-48914 TS-48915
10066-340EA 221.24 USD
10066-340 10066-342 10066-344 10066-346 10066-348
Silylation Reagents
Chromatography Sorbents GC Sorbents

Silylation reagent for GC analyzes of early eluting compounds that would otherwise be obscured in the chromatogram.


  • Trimethylsilyl donor strength comparable to BSA and BSTFA
  • Reacts to replace labile hydrogens on a wide range of polar compounds with a Si(CH₃)₃ group
  • Used to prepare volatile and thermally stable derivatives for GC and MS
  • Volatile byproduct, N-methyltrifluoroacetamide, has an even lower retention time than MSTFA


MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide), the most volatile TMS-amide and its byproduct N-methyltrifluoroacetamide typically elute with the solvent front, allowing TMS derivatives of small molecules to be analyzed.


MSTFA + 1% TMCS is ideal for derivatization of amides, secondary amines, and hindered hydroxyls.


Storage temperature: 2 to 8 °C

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