SensoLyte® 520 MMP-12 Assay Kit (Fluorimetric), AnaSpec

Supplier: AnaSpec

AS-71157

103010-244EA 809.69 USD

103010-244

SensoLyte® 520 MMP-12 Assay Kit (Fluorimetric), AnaSpec

Assays Enzyme Assays

Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

SensoLyte® 520 MMP-12 Assay Kit uses a 5-FAM (fluorophore) and QXL520™ (quencher) labeled FRET peptide substrates for continuous measurement of the enzyme activities. This substrate showed excellent specificity to MMP-12 with minimal cross-reaction with MMP-1, 2, 7, 8, 9, 9, 13 and 14. In an intact FRET peptide, the fluorescence of 5-FAM is quenched by QXL520™. Upon the cleavage of the FRET peptide by MMP-12, the fluorescence of 5-FAM is recovered, and can be continuously monitored at excitation/emission = 490 nm/520 nm. With superior fluorescence quantum yield and longer emission wavelength, 5-FAM/QXL520™ based FRET peptide is less interfered by the autofluorescence of test compounds and cellular components and provides better assay sensitivity. The assays are performed in a convenient 96-well or 384-well microplate format.

MMP-12 (macrophage elastase) is expressed in activated macrophages and may play a role in smoke-induced emphysema.

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