Ribavirin
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Warning
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Synonyms:
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide
Ribavarin is an antiviral compound reported to be active against RSV, HIV, HCV and other infectious agents. Its metabolite, ribavirin 5'-phosphate, inhibits inosine monophosphate dehydrogenase (IMP). It is also an analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.
Ribavirin is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of viral genetic material.
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.
Antiviral agent whose metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.
Store at +4 °C.
- Presentation: White Powder
- Soluble in water (20 mg/mL - clear, colorless solution).
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Formula:
C8H12N4O5 MW: 244.2047 g/mol Melting Pt: 173 °C (lit.) Storage Temperature: Refrigerator |
MDL Number:
MFCD00058564 CAS Number: 36791-04-5 |
Specification Test Results
| Identity Test | Passes |
| Purity | ≥99% |
| Specific Rotation | Between -33.5° and -37.0° |
| pH | 4.0-6.5 |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.25% |
| Heavy Metals | ≤0.001% |
| Chromatographic Purity | Individual Peak ≤0.25% |
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