Indomethacin
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Indomethacin, an anti-inflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM).
- Anti-inflammatory
- Adipogenic
- ligand-activated
- pKa=4.5 (Lit.)
Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.
Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.
EmM (230 nm)=20.8 (in ethanol), EmM (260 nm)=16.2 (in ethanol), EmM (319 nm)=6.29 (in ethanol),(Lit)
Off-white powder
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
Formula:
C₁₉H₁₆ClNO₄ MW: 357.80 g/mol Melting Pt: 152…165 °C Storage Temperature: Ambient |
MDL Number:
MFCD00057095 CAS Number: 53-86-1 UN: 2811 ADR: , |
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