Neomycin sulfate ≥600 µg/mg USP
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
Neomycin, (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulphate, Fradiomycin sulphate, Neomycin sulphate salt
This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis.
- Binds to subunits
- Blocks Ca2+ channels
- Produced by Streptomyces
- Loss on drying: <8.0%
- pH: 5-7.5
- Physical form: Poweder
Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
Neomycin acts against both gram-positive and gram-negative bacteria.
Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins.
It is recommended for use in cell culture applications at 50 mg/L.
Soluble in Water (50 mg/mL)
Formula:
C₂₃H₄₆N₆O₁₃·3H₂SO₄ MW: 908.87 g/mol Storage Temperature: Ambient |
MDL Number:
MFCD00150827 CAS Number: 1405-10-3 |
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