Doxorubicin hydrochloride ≥95%
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
Doxorubicin HCl, Hydroxydaunorubicin Hydrochloride, (8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis.
- Inhibits nucleic Acid synthesis
- Induces apoptosis
- Substrate of MRP1
Naturally fluorescent anthracycline antibiotic, anticancer drug
Doxorubicin Hydrochloride is a chemotherapeutic, antitumor, immunosuppressive, and antibiotic agent.
Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
Reddish orange powder
Soluble in water (>10 mg/mL), in isotonic sodium chloride, methanol, aqueous alcohols, DMSO (> 10 mg/mL); practically insoluble in chloroform, ether, and other organic solvents.
Formula:
C₂₇H₂₉NO₁₁·HCl MW: 579.98 g/mol Melting Pt: 216 °C (dec., lit.) Storage Temperature: Ambient |
MDL Number:
MFCD00077757 CAS Number: 25316-40-9 |
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