Doxycycline hyclate ≥98.0% (by HPLC), Powder

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Synonyms: Doxycycline Hydrochloride Hemiethanolate Hemihydrate

D9891-10G D9891-25G D9891-5G D9891-1G D9891-100G
220123-511EA 292.92 USD
220123-511 220123-513 220123-514 220123-512 220123-510
Doxycycline hyclate ≥98.0% (by HPLC), Powder
Doxycycline hyclate

Doxycycline hyclate is a synthetic oxytetracycline derivative


  • pKa: 3.5, 7.7, 9.5 (20 °C)
  • Ɣmax: 351 nm, 267 nm
  • Extinction Coefficient: EmM= 13.2 (351 nm), 17.4 (267 nm) (10 mM HCl in methanol)
  • Specific Rotation: -110 (10 mg/ml, 10 mM HCl in methanol)
  • Solubility in water: 50 mg/L


It can be used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks and also to inhibit matrix metalloproteinases and inflammatory response to the Lyme disease Spirochete Borrelia burgdorfer.

Formula: C₂₂H₂₄N₂O₈·HCl·0.5H₂O·0.5C₂H₆O
MW: 512.94 g/mol (503.94 anhy)
Melting Pt: 201 °C
Storage Temperature: Refrigerator
MDL Number: MFCD07357237
CAS Number: 24390-14-5

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Specification Test Results

Appearance (Color) Yellow and Yellow-Green
Appearance (Form) Powder
Solubility (Color) at 50 mg/ml Water Yellow to Very Dark Yellow and Green-Yellow to Very Dark Green-Yellow and Yellow-Green
Solubility (Turbidity) Clear
Water ≤5%
Nitrogen Content (Anhydrous and solvent-free basis) 5.50 - 6.10 %
Purity (HPLC) ≥98.0%
Residual Solvents (GLC-HS) % Ethanol ≤7.0%

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