Sulfo-NHS (N-Hydroxysulfosuccinimide sodium salt), Pierce™
Supplier: LIFE TECHNOLOGIES MS
Synonyms:
N-Hydroxy sulphosuccinimide sodium salt, Hydroxy-2,5-dioxopyrrolidine-3-sulphonic acid sodium salt, N-Hydroxysulphosuccinimide sodium salt, Sulfo NHS, Sulpho-N-Hydroxysuccinimide
Pierce™ Sulfo-NHS (N-hydroxysulfosuccinimide) is a chemical modification reagent for converting carboxyl groups to amine-reactive NHS esters for bioconjugation, crosslinking, labeling and immobilization methods.
- Improve efficiency of EDC coupling reactions
- Water-soluble and membrane-impermable
- Activate nanoparticles with amine-reactive Sulpho-NHS esters
- Crosslink proteins to carboxyl-coated beads or surfaces more efficiently
Sulfo-NHS (N-hydroxysulfosuccinimide) enables control and modification of carbodiimide crosslinking reactions involving activation of carboxylates (—COOH) for conjugation with primary amines (—NH2). Derivatives are easily synthesized by mixing the Sulfo-NHS with a carboxyl-containing molecule and a dehydrating agent such as the carbodiimide EDC (EDAC). The method is the basis for generating many types of protein labeling reagents, including amine-reactive fluorescent dyes, biotin affinity tags and pegylation compounds.
Precaución: For Research Use Only. Not for use in diagnostic procedures.
Formula:
C₄H₄NNaO₆S MW: 217.13 g/mol |
MDL Number:
MFCD00043100 CAS Number: 106627-54-7 |
Specification Test Results
Product Line | Pierce™ |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Reactive Moiety | Carbodiimide |
Spacer | Short |
Form | Powder |
Quantity | 500 mg |
Type | Crosslinker |
Solubility | Water |
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