N,O-Bis(trimethylsilyl)trifluoroacetamide

Supplier: RESTEK CORP
Danger

Synonyms: Trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate, Bis(Trimethylsilyl)Trifluoroacetamide, BSTFA

35604 35605
75835-942PK 93.21 USD
75835-942 75835-944
N,O-Bis(trimethylsilyl)trifluoroacetamide
N,O-Bis(trimethylsilyl)trifluoroacetamide

Silylation derivatization reagent.


  • Replace active hydrogen, reducing polarity and making the compounds more volatile
  • Increase stability of derivatives


Silylation is the most widely used derivatization procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group such as trimethylsilyl (TMS) or tert-butyldimethylsilyl (tert-BDMS). Silyl derivatives are more volatile, less polar, and more thermally stable. As a result, GC separation is improved and detection is enhanced.


Both TMS and tert-BDMS reagents are suitable for a wide variety of compounds and can be used for many GC applications. (Note that silylation reagents are generally moisture-sensitive and must be sealed to prevent deactivation.)

Formula: C₈H₁₈F₃NOSi₂
MW: 257.4 g/mol
MDL Number: MFCD00008269
CAS Number: 25561-30-2
UN: 1993
ADR: 3,II

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