Diisopropylethylamine resin (MP), beads, macroporous 330-1225 µm, 15-50 mesh(>90% within) Loading: 2.4-2.8 mmol/g
Supplier: Supra Sciences
Solid supported tertiary amine useful in all acid scavenging protocols.
Diisopropylethylamine Resin, MP, is a macroporous resin functionalized with a diisopropyl end group and is functionally equivalent to Huenig’s Base. It is very effective in reactions that produce acidic byproducts. MP-DIEA is extremely efficient in sequestering HCl formed during amide, sulfonamide and carbamate synthesis. When it is combined with MP-Trisamine (scavenges excess acid, sulfonyl and carbamoyl chlorides) the result is a one-pot synthesis, which requires only filtration to isolate the desired product. The steric bulk associated with the two isopropyl groups severely inhibits the nucleophilicity of the amine towards electrophilic partners, therefore removing the possibility of reaction byproducts arising from the resin itself.
Specification Test Results
Colour | Off-white |
Form | Granule |
Loading | 1.2-1.4 mmol/g |
Particle size | 330-1225 μm (15-50 mesh) |
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